{"title":"Sustained Release (PODS)","description":null,"products":[{"product_id":"pods-empty","title":"PODS Empty","description":"\u003cp\u003eNOTE: PODS® Empty crystals are composed solely of polyhedrin protein. As these PODS® do not contain any cargo protein, they are sold by weight of the polyhedrin protein, rather than cargo weight. This product is intended to be used as a negative control alongside cargo-containing PODS® co-crystals. The cross-reactivity of PODS® Empty crystals has been tested on a variety of cells including mouse ES cells, PC12, fibroblasts, and ETS embryos, and there was no observable interference with the tested cells. Additionally, in-vivo data indicate no inflammatory response to PODS® Empty crystals in animals.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"0.5 mg","offer_id":49302508634368,"sku":"CGS-PP302-0.5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"2.5 mg","offer_id":49302508667136,"sku":"CGS-PP302-2.5","price":557.03,"currency_code":"NZD","in_stock":true},{"title":"25 mg","offer_id":49302508699904,"sku":"CGS-PP302-25","price":1352.78,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1.jpg?v=1787289843"},{"product_id":"pods-ff-luciferase","title":"PODS FF luciferase","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with luciferase. When mixed with its substrate, luciferin, luciferase is luminescent.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302508732672,"sku":"CGS-PP305-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302508765440,"sku":"CGS-PP305-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302508798208,"sku":"CGS-PP305-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302508830976,"sku":"CGS-PP305-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_7ebbe014-c82a-4436-a3ba-99859789f96d.jpg?v=1787289845"},{"product_id":"pods-gfp","title":"PODS GFP","description":"\u003cp\u003eThis GFP product contains polyhedrin protein co-crystalized with Green Fluorescent Protein (GFP). GFP is a uniquely versatile biomarker and, encased into PODS® crystals, offers a simple way to visualize und localize PODS® crystals embedded in biomaterials, such as hydrogels and scaffolds, using fluorescence microscopy. PODS® GFP crystals can be excited at 488 nm and optimally detected at 510 nm, compatible with commonly available filter sets.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302514204928,"sku":"CGS-PP303-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302514237696,"sku":"CGS-PP303-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302514270464,"sku":"CGS-PP303-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302514303232,"sku":"CGS-PP303-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_c0082ee2-e25d-4ca8-9435-20655637eef9.jpg?v=1787289847"},{"product_id":"pods-human-activin-a","title":"PODS Human Activin A","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human Activin A. Activin A is a member of the Transforming Growth Factor beta (TGF-?) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine\/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin beta A chains. Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302514368768,"sku":"CGS-PPH6-5","price":143.23,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302514401536,"sku":"CGS-PPH6-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302514434304,"sku":"CGS-PPH6-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302514467072,"sku":"CGS-PPH6-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_2f7e9db4-a9d7-42cf-ba95-93a64966d02c.jpg?v=1787289849"},{"product_id":"pods-human-activin-b","title":"PODS Human Activin B","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human Activin B. Activin B is a member of the TGF-? superfamily, which are disulfide-linked dimeric proteins that were originally purified from gonadal fluids and had as primary role to stimulate the release of pituitary follicle stimulating hormones (FSH). Activin B has shown to have a wide range of biological activities including: mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, reproductive physiology, and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activins exert their biological activities through binding to the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated as type I and type II. Two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B) have been identified. Activin B signals through the ActRII receptor (Activin Receptor type II).\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302519841024,"sku":"CGS-PPH307-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302519873792,"sku":"CGS-PPH307-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302519906560,"sku":"CGS-PPH307-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302519939328,"sku":"CGS-PPH307-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_c2293952-3583-4e31-a82f-5226769de09b.jpg?v=1787289850"},{"product_id":"pods-human-bdnf","title":"PODS Human BDNF","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BDNF. Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival. BDNF expression in the hippocampus is essential for long-term memory storage and learning. Some protein domains of BDNF are identical with those of NGF and another neurotrophic factor, designated NT-3 (Neurotrophin-3). Human, mouse, rat, and pig BDNF are cross-reactive.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302520004864,"sku":"CGS-PPH1-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302520037632,"sku":"CGS-PPH1-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302520070400,"sku":"CGS-PPH1-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302520103168,"sku":"CGS-PPH1-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_be218b6a-a4a5-40da-925d-7bbb86e659ae.jpg?v=1787289852"},{"product_id":"pods-human-beta-ngf","title":"PODS Human Beta-NGF","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human Beta-NGF (NGF-β). Beta-NGF  is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF is also involved in the growth, differentiation, and survival of B lymphocytes.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302525477120,"sku":"CGS-PPH317-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302525509888,"sku":"CGS-PPH317-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302525542656,"sku":"CGS-PPH317-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302525575424,"sku":"CGS-PPH317-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_c8c5e219-d947-4921-bdf2-d21e26c19788.jpg?v=1787289853"},{"product_id":"pods-human-bmp-10","title":"PODS Human BMP-10","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BMP-10. Bone Morphogenic Protein 10 (BMP-10) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilage growth. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. In dermal endothelial cells, BMP-10 plays a role in migration, proliferation, and gene expression.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302525640960,"sku":"CGS-PPH308-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302525673728,"sku":"CGS-PPH308-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302525706496,"sku":"CGS-PPH308-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302525739264,"sku":"CGS-PPH308-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_d7dd742c-a617-408e-9388-33d04ddc44e6.jpg?v=1787289855"},{"product_id":"pods-human-bmp-2","title":"PODS Human BMP-2","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BMP-2. Bone Morphogenic Protein 2 (BMP-2) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP-2 functions as a potent inducer of bone and cartilage development. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjunction with SMAD proteins to directly promote osteoblast differentiation. BMP-2 is also important during cardiac development and supports epicardial cell migration.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302525772032,"sku":"CGS-PPH53-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302525804800,"sku":"CGS-PPH53-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302525837568,"sku":"CGS-PPH53-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302525870336,"sku":"CGS-PPH53-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_c974bef1-e97b-4d15-8281-9d3b978141b1.jpg?v=1787289857"},{"product_id":"pods-human-bmp-3","title":"PODS Human BMP-3","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BMP-2. Bone Morphogenic Protein 2 (BMP-2) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP-2 functions as a potent inducer of bone and cartilage development. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjunction with SMAD proteins to directly promote osteoblast differentiation. BMP-2 is also important during cardiac development and supports epicardial cell migration.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302531244288,"sku":"CGS-PPH54-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302531277056,"sku":"CGS-PPH54-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302531309824,"sku":"CGS-PPH54-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302531342592,"sku":"CGS-PPH54-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_c227b9aa-174f-4c3f-949e-aae1f82ac6d1.jpg?v=1787289859"},{"product_id":"pods-human-bmp-4","title":"PODS Human BMP-4","description":"","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302531440896,"sku":"CGS-PPH56-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302531473664,"sku":"CGS-PPH56-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302531506432,"sku":"CGS-PPH56-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302531539200,"sku":"CGS-PPH56-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/Cell_Guidance_Systems_b73f429a-74c6-44e3-97fe-87f229a95686.png?v=1787519563"},{"product_id":"pods-human-bmp-5","title":"PODS Human BMP-5","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BMP-5. BMP-5, also known as Bone Morphogenetic Protein 5, is a member of the TGF superfamily of proteins. Akin to the other functionally and structurally related bone morphogenic proteins (BMPs), BMP-5 is involved in cartilage and bone formation as BMP-5, along with BMP-6 and BMP-7, shares high sequence homology with BMP-2. Furthermore, BMP-5 is expressed by chondrocytes in proliferating bone growth plates and contributes to limb development by promoting proliferation and differentiation of chondrocytes as well as apoptosis of undifferentiated mesoderm. Outside the context of bone and cartilage, BMP-5 is expressed in the lung and liver as well as the trabecular meshwork and optic nerve head where it may have a role in the development and normal function. Furthermore, in the developing as well as adult nervous system, BMP-5 promotes dendrite outgrowth, morphology and dopaminergic neuronal differentiation. Analogous to other BMPs, BMP-5 is a disulfide-linked homodimer and highly conserved across animal species.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302536913152,"sku":"CGS-PPH57-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302536945920,"sku":"CGS-PPH57-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302536978688,"sku":"CGS-PPH57-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302537011456,"sku":"CGS-PPH57-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_5107d7fd-9527-45a2-8769-eed72df1f060.jpg?v=1787289862"},{"product_id":"pods-human-bmp-7","title":"PODS Human BMP-7","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BMP-7. BMP-7, also known as Bone Morphogenetic Protein 7, osteogenic protein-1 or OP-1, is a member of the TGF superfamily of proteins. Akin to the other functionally and structurally related bone morphogenic proteins (BMPs), BMP-7 is involved in cartilage and bone formation and signals through serine\/threonine kinase receptors. Additionally, BMP-7 plays a role in a variety of other organs and organ systems such as during development of the kidney and prostate. Furthermore, BMP-7 has been identified as an anti-fibrotic molecule, antagonizing TGF-?1 and the emergence of fibroblasts derived from endothelial cells in fibrosis of kidney, lung, liver, heart and peritoneum. BMP-7 was also implicated in the promotion of neuroregeneration following brain ischemia. The BMP-7 protein is usually a disulfide-linked homodimer and highly conserved across animal species; for example, the amino acid sequence of human, mouse and rat BMP-7 are 98% identical. However, mature BMP-7 can also form disulfide-linked heterodimers with either BMP-2 or BMP-4. These hetrodimeric complexes have shown increased effects and range of activity compared to BMP-7 homodimers.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302537044224,"sku":"CGS-PPH58-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302537076992,"sku":"CGS-PPH58-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302537109760,"sku":"CGS-PPH58-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302537142528,"sku":"CGS-PPH58-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_d556748e-af4a-46b5-9bdb-e989957258a4.jpg?v=1787289864"},{"product_id":"pods-human-ccl13","title":"PODS Human CCL13","description":"\u003cp\u003eI'll fetch each unique URL and extract the product description sections, then output them in the order you specified.The product contains the polyhedrin protein co-crystalized with Human CCL13. A member of the CC sub-family of chemokines, CCL13 signals primarily via the CC chemokine receptors CCR2B and CCR3. It is a chemoattractant for monocytes, lymphocytes, basophils and eosinophils. It is also involved in the accumulation of leukocytes at the sites of allergic and non-allergic inflammation. The activity of this protein can be induced via several inflammatory cytokines, including interleukin-1 and TNF-?.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302542483712,"sku":"CGS-PPH132-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302542516480,"sku":"CGS-PPH132-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302542549248,"sku":"CGS-PPH132-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302542582016,"sku":"CGS-PPH132-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_7ac34be1-56b5-4ea7-85d9-b663e128faad.jpg?v=1787289866"},{"product_id":"pods-human-ccl4","title":"PODS Human CCL4","description":"","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302542614784,"sku":"CGS-PPH134-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302542647552,"sku":"CGS-PPH134-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302542680320,"sku":"CGS-PPH134-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302542713088,"sku":"CGS-PPH134-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/Cell_Guidance_Systems_7f21d3de-2464-44d5-a6de-11fd6a6bd273.png?v=1787519564"},{"product_id":"pods-human-cd40-ligand","title":"PODS Human CD40 Ligand","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human CD40 Ligand. CD40 Ligand is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40 Ligand binds and activates the CD40 receptor on antigen-presenting cells. CD40 Ligand stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40 Ligand also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40 Ligand is a co-stimulator of activated T cell proliferation and inflammatory protein production.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302548054272,"sku":"CGS-PPH25-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302548087040,"sku":"CGS-PPH25-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302548119808,"sku":"CGS-PPH25-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302548152576,"sku":"CGS-PPH25-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_541e920a-9b0a-4e7a-ac96-e6fc5ada12b2.jpg?v=1787289869"},{"product_id":"pods-human-cdnf","title":"PODS Human CDNF","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human CDNF. Cerebral Dopamine Neurotrophic Factor (CDNF) and MANF (mesencephalic-astrocyte-derived neurotrophic factor) are structural homologues and share 62% amino acid (aa) identity. Furthermore, CDNF is highly conserved across species. It shares 80%, 84%, 90% and 92% aa identity with mouse, rat, equine and bovine CDNF, respectively. Like MANF and GDNF, CDNF is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine-specific neurons (DNs) in vitro. Additionally, in rat Parkinson's disease models that rely on 6-hydroxydopamine (6-OHDA)-induced degeneration of DNs, CDNF can also promote rescue and restoration of DNs in the substania nigra in vivo.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302553493760,"sku":"CGS-PPH347-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302553526528,"sku":"CGS-PPH347-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302553559296,"sku":"CGS-PPH347-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302553592064,"sku":"CGS-PPH347-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_a574f545-9502-41be-9908-ebf7482e3392.jpg?v=1787289871"},{"product_id":"pods-human-chemerin","title":"PODS Human Chemerin","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human Chemerin. Chemerin is a chemoattractant adipokine that is expressed in white adipose, liver, skin, and lung tissues. Chemerin is a ligand for the G protein-coupled receptor chemokine-like receptor 1 (ChemR23), which is expressed on dendritic cells, macrophages, and adipocytes. Chemerin functions to recruit macrophages to sites of tissue damage and inflammation. 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CXCL12, C-X-C motif chemokine 12 (CXCL12), is also known as Stromal cell-derived factor 1 ? (SDF1 ?). CXCL12 acts as a chemoattractant active on monocytes and T-lymphocytes but not neutrophils. The binding of CXCL12 to CXC receptor 4 (CXCR4) induces intracellular signalling through several divergent pathways which are implicated in chemotaxis, increase in intracellular calcium, cell survival and\/or proliferation, and gene transcription. CXCL12 has diverse cellular functions including embryogenesis, tissue homeostasis, immune surveillance, inflammation, and tumour growth and metastasis. 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The N-terminus extensions influence the localization of FGF-2 within the cell, but do not affect the biological activity of FGF-2.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302603464960,"sku":"CGS-PPH146-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302603497728,"sku":"CGS-PPH146-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302603530496,"sku":"CGS-PPH146-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302603563264,"sku":"CGS-PPH146-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_a2a849d0-5df8-4bcc-b1c3-954e929dc7dd.jpg?v=1787289900"},{"product_id":"pods-human-fgf-20","title":"PODS Human FGF-20","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human FGF-20. 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Fibroblast Growth Factor 4 (FGF-4) is a secreted growth factor that is predominantly expressed during bone morphogenesis and embryonic limb development. FGF-4 is an important growth regulator for stem cells, fibroblasts, and endothelial cells. FGF-4 contains a single N-linked glycosylation signal. However, in vitro studies suggest that unglycosylated FGF-4 is cleaved into 13 kDa and 15 kDa truncated proteins that have greater biological activity than the wild type 19 kDa FGF-4 protein. 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Fibroblast Growth Factor 7 (FGF-7), also known as Keratinocyte Growth Factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectoderm ridge during limb development.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302614638848,"sku":"CGS-PPH187-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302614671616,"sku":"CGS-PPH187-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302614704384,"sku":"CGS-PPH187-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302614737152,"sku":"CGS-PPH187-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_44c06cc5-aef8-4f86-b223-8c3031f371d0.jpg?v=1787289907"},{"product_id":"pods-human-follistatin","title":"PODS Human Follistatin","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human Follistatin. Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of Transforming Growth Factor ? (TGF-?) family members, such as activin, bone morphogenic proteins (BMP), myostatin, Growth Differentiation Factor 11 (GDF-11), and TGF-?1. Follistatin functions as an antagonist by binding TGF-? family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of Follicle-Stimulating Hormone (FSH) from the anterior pituitary.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302620078336,"sku":"CGS-PPH41-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302620111104,"sku":"CGS-PPH41-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302620143872,"sku":"CGS-PPH41-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302620176640,"sku":"CGS-PPH41-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_8166e4b6-fd2c-4ca6-b44a-1dba0ebdfdf2.jpg?v=1787289909"},{"product_id":"pods-human-g-csf","title":"PODS Human G-CSF","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human G-CSF. Granulocyte-Colony Stimulating Factor (G-CSF) is a cytokine that functions as a potent inducer of neutrophilic granulocyte proliferation, terminal differentiation, and activation. G-CSF synthesis occurs in monocyte, macrophage, epithelial, endothelial, and fibroblast cells after activation by bacterial endotoxins, Tumor Necrosis Factor ? (TNF-?), Interleukin-1 (IL-1), or Interleukin-17 (IL-17). The functional activity of G-CSF is mediated through the granulocyte colony-stimulating factor receptor (G-CSF-R) to activate JAK\/STAT and MAPK signal transduction pathways. G-CSF also promotes neurogenesis and inhibits neuronal apoptosis. Human and mouse G-CSF proteins are cross-reactive.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302625517824,"sku":"CGS-PPH72-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302625550592,"sku":"CGS-PPH72-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302625583360,"sku":"CGS-PPH72-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302625616128,"sku":"CGS-PPH72-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_6469c616-1f5f-4c99-8528-0aa04e5a2a33.jpg?v=1787289911"},{"product_id":"pods-human-gastrin","title":"PODS Human Gastrin","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human Gastrin. 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Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signalling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302631121152,"sku":"CGS-PPH2-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302631153920,"sku":"CGS-PPH2-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302631186688,"sku":"CGS-PPH2-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302631219456,"sku":"CGS-PPH2-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_a8131062-b7a0-4905-aad9-046e369a7c31.jpg?v=1787289915"},{"product_id":"pods-human-gm-csf","title":"PODS Human GM-CSF","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human GM-CSF. Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells. GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells. GM-CSF promotes immune system development and regulates neutrophil function during infection. 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(IFN-?) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-? is produced by T cells and Natural Killer cells following antigen-specific activation. IFN-? binds IFN-? receptors (IFN-? R1 and IFN-? R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-? induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. 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IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302642131200,"sku":"CGS-PPH34-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302642163968,"sku":"CGS-PPH34-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302642196736,"sku":"CGS-PPH34-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302642229504,"sku":"CGS-PPH34-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_a740d0bf-bda3-4197-a068-15115a2f1c6c.jpg?v=1787289920"},{"product_id":"pods-human-igf-1-l3r","title":"PODS Human IGF-1 L3R","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human IGF-1 L3R. Insulin-like Growth Factor 1 (IGF-1) is a growth factor that is produced by the liver. IGF-1 production is stimulated by Growth Hormone. IGF-1 binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-1 is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302642262272,"sku":"CGS-PPH328-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302642295040,"sku":"CGS-PPH328-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302642327808,"sku":"CGS-PPH328-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302642360576,"sku":"CGS-PPH328-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_931ddf27-3da2-45b8-bedb-cb08cdf76dab.jpg?v=1787289922"},{"product_id":"pods-human-il-10","title":"PODS Human IL-10","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human IL-10. Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon-gamma (IFN-gamma), Tumor Necrosis Factor alpha (TNF-alpha), interleukin-2 (IL-2), interleukin-3 (IL-3), interleukin-4 (IL-4), and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. 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It is also used for expansion of NK cells, early differentiated T cells and effector memory Treg cells for cancer immunotherapy.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302663921920,"sku":"CGS-PPH12-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302663954688,"sku":"CGS-PPH12-25","price":348.14,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302663987456,"sku":"CGS-PPH12-250","price":1690.98,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302664020224,"sku":"CGS-PPH12-1000","price":5570.29,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_03c7f9d4-41bf-4269-b33a-b0bb733df620.jpg?v=1787289932"},{"product_id":"pods-human-il-3","title":"PODS Human IL-3","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystallized with Human IL-3. 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Also known as NF-HEV and DVS 27, IL-33 is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. It is a proinflammatory cytokine which binds and signals through the IL-1RL1\/ST2 receptor to activate NF-?-B and MAPK signalling pathways. IL-33 functions to induce type 2-associated cytokine production in polarized Type 2 helper T (Th2) cells.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302669525248,"sku":"CGS-PPH145-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302669558016,"sku":"CGS-PPH145-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302669590784,"sku":"CGS-PPH145-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302669623552,"sku":"CGS-PPH145-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_6c92de44-17bb-4be6-b114-0b97fb880f74.jpg?v=1787289935"}],"url":"https:\/\/shop.customscience.co.nz\/collections\/cells-and-tissue-growth-factors-and-cytokines-sustained-release-pods.oembed","provider":"Custom Science Ltd","version":"1.0","type":"link"}