Small Molecules

Y-27632 dihydrochloride is a water-soluble Rho-associated protein Kinase (ROCK) inhibitor.

XAV939 is a beta-catenin-mediated transcription inhibitor of selective Wnt pathway. Alternatively, it acts as axin stabilizing agent for the inhibi...

WH-4-023 is a potent and selective inhibitor for Lck and Src kinase. It poorly inhibits p38 alpha and KDR.

Vandetanib is an antagonist of VEGFR and EGFR families. Specifically inhibits kinase activity of Flk-1. It is also an inhibitor of Flt-4. Vandetani...

U0126 is a selective MAP Kinase inhibitor, displaying a preference for MEK-1 and MEK-2. It is known that U0126 binds to MEK in a noncompetitive man...

TWS119 is a cell-permeable pyrrolopyrimidine compound that acts as a glycogen synthase kinase-3 beta (GSK-3 beta) inhibitor. TWS119 is thought to b...

Trichostatin A is a potent and specific inhibitor of histone deacetylase (HDAC).

Thiazovivin is a selective, cell permeable small molecule that directly inhibits Rho-associated kinase.

TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor.TG101348 also inhibits FLT3 and RET.

Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Ty...

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR beta. It also inhibits c-Kit. Sunitinib inhibits cellular receptor p...

SU6668 is an ATP-competitive PDGFR, Flk-1/KDR and FGFR inhibitor. It presents little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2. I...

SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. Multip...

StemRegenin 1 is an AhR inhibitor. StemRegenin 1 induces CD34+ cell expansion by binding and antagonizing AhR.

Staurosporine is a potent inhibitor of phospholipid/calcium-dependent protein kinase. It also inhibits the upregulation of VEGF expression in tumor...

Stauprimide is an indolocarbazole semi-synthetic small molecule. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating...

SP600125 is a potent, selective and reversible inhibitor of the three JNK enzymes (c-Jun N-terminal kinases). Inhibition is competitive with respec...

Sorafenib is a multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth ...

SB590885 is another selective small-molecule inhibitor of the B-Raf kinase. It has been used to overcome the dependence of MAPK signaling and tumor...

SB431542 is a potent and selective inhibitor of the TGF-β superfamily type 1 (TGF-β 1) activin receptor-like kinase (ALK5) receptors, and its relat...

SB216763 is a potent, selective, and cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor. It competes with ATP and potently inhibits the ac...

SB203580 is a specific inhibitor of p38-MAPK pathway. SB203580 also inhibits protein kinase B (PKB, also known as Akt) and TLR signaling pathway.

SAHA (suberoylanilide hydroxamic acid) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs.

Ruxolitinib is a JAK inhibitor of JAK1, JAK2, and JAK3. JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are kno...