Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase to endosomes from the Golgi and back again. Cargo selection protein TIP47, also designated placental protein 17, is required for the transport from endosomes to the trans-Golgi network and interacts with the cytoplasmic domains of both cation-dependent and cation-independent MPRs. Another member of the peripilin family, Adipophilin (ADRP), is a protein associated with the globule surface membrane material of milk lipid globules. The phos-phoprotein Perilipin (Peri) is located on the surface of intracellular lipid droplets within adipocytes where it protects lipid storage droplets by coating them in adipocytes until they are digested by lipase. As a critical regulator of lipolysis, elevated Perilipin levels have been linked to obesity.