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AR ?2A (R361) polyclonal antibody detects endogenous levels of AR ?2A protein.

SKU BW-BS2254-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14 - $616.38
Current price $354.14

This study investigates the involvement of ?2-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that ?2A-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal ?2A-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, ?1D-AR, were not changed by the treatment. Moreover, ?o-subunits of GTP-binding proteins (G?o), one of the downstream molecules of ?2A-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of ?2A-AR in the mouse hippocampus.

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