Arylsulfatase E, also known as CDPX, CDPX1 or CDPXR, is a 589 amino acid Golgi apparatus protein expressed in the pancreas, liver and kidney. Belonging to the sulfatase family, Arylsulfatase E may be essential for the correct composition of cartilage and bone matrix during development. Inhibited by warfarin, Arylsulfatase E activity occurs under optimal pH and temperature. Defects in the gene encoding Arylsulfatase E are the cause of chondrodysplasia punctata X-linked recessive type 1 (CDPX1), which is characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage and distal phalangeal hypoplasia. Arylsulfatase E has no activity toward steroid sulfates.