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BACE1 polyclonal antibody detects endogenous levels of BACE1 protein.

SKU BW-BS71952-50ul
Original price $466.21 - Original price $802.41
Original price
$466.21
$466.21 - $802.41
Current price $466.21

Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the ?-amyloid protein precursor (APP). Amyloid ?-peptide(A?), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by ?- and ?-secretases. BACE is the transmembrane protease which cleaves A? from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE has a molecular mass of ~70 kDa, larger than predicted due to glycosylation, and is localized within Golgi and endosomes.

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