Epithelial-derived neutrophil-activating peptide 78 (ENA-78), also known as CXCL5, is a chemokine that recruits neutrophils, promotes angiogenesis, and stimulates connective tissue remodelling. ENA-78 production is stimulated by Interleukin-1 (IL-1) or tumor Necrosis Factor ? (TNF-?), and signals through the chemokine receptor CXCR2. ENA-78 with 5 - 78 aminoacids is one of three naturally occuring ENA-78 variants in which the N-terminus has been truncated.