![GATA4 (R306) polyclonal antibody detects endogenous levels of GATA4 protein.](http://shop.customscience.co.nz/cdn/shop/products/Antibody_42af3221-7b81-40fa-8ddd-1550387e43d8_717x700.gif?v=1690467964)
GATA4 (R306) polyclonal antibody detects endogenous levels of GATA4 protein.
GATA4 is a 46 kDa member of the GATA family of zinc finger containing transcription factors that is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs.
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