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IL-3R (F587) polyclonal antibody detects endogenous levels of IL-3R protein.

SKU BW-BS1185-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific ? subunit (IL-3R?) and a signal transducing ? subunit (IL-3R?) common to the IL-3/IL-5/GM-CSF receptors. The ? subunits are low-affinity ligand-binding proteins while the ? subunits do not themselves bind ligand, but are required for high affinity binding by the ? subunits. The mouse IL-3 receptor has two distinct ? subunits, one that functions only in IL-3-mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine ? subunits are 91% homologous at the amino acid level but only 56% homologous to the human ? subunit.

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