
IL-4R/CD124(Tyr497) polyclonal antibody detects endogenous levels of HIST1H3A protein.
The IL-2 receptor is a multicomponent complex consisting of three subunits, ?,? and ?, each of which is required for high affinity binding of IL-2. The ? chainfunctions primarily in binding IL-2, whereas the ? and ? chains contribute toIL-2 binding and are essential to IL-2-induced activation of signaling pathwaysleading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is nowwell established that the IL-2R? chain functions as a second subunit of thehigh affinity IL-4R and IL-7R receptors. Consequently, the originally describedsubunits of these latter receptors are now referred to as IL-4R? and IL-7R?,respectively, while the common subunit is referred to as ?c. Although the common ? chain enhances ligand binding in these three cytokine receptors, ithas no capacity to bind these ligands on its own. There is evidence that the?c chain is also a subunit of IL-13R.
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