p-CKR-5 (S349) polyclonal antibody detects endogenous levels of CKR-5 protein only when phosphorylated at Ser349.
The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells.
Delivery time
Overnight if in stock
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Purchase orders from approved customers and Credit Cards are accepted as forms of payment