p-PYK2 (Y580) polyclonal antibody detects endogenous levels of PYK2 protein only when phosphorylated at Tyr580.
Pyk2 is a protein tyrosine kinase related to Focal Adhesion Kinase (p125 FAK). Pyk2 is highly expressed in the central nervous system. It is phosphorylated on tyrosine residues in response to various stimuli that elevate intracellular calcium concentration, as well as by protein kinase C activation.
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