p-Synuclein-? (S129) polyclonal antibody detects endogenous levels of Synuclein-? protein only when phosphorylated at Ser129
The synuclein family members, including ?-synuclein (also designated NACP for non-? Amyloid component) and ?-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. ?-synuclein is localized to neuronal cell bodies and synapses. ?-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation ?-synuclein has been found to be upregulated, while ?-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of ?-synuclein has been found in patients with early onset Parkinson’s disease.
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