PI3K p85?/p55? (phospho-Y467/Y199) polyclonal antibody detects endogenous levels of PI3K p85? only when phosphorylated at Tyr467. This antibody also detects PI3K p55? when phosphorylated at Tyr199.
The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Delivery time
Overnight if in stock
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Purchase orders from approved customers and Credit Cards are accepted as forms of payment