{"product_id":"pods-human-bmp-7","title":"PODS Human BMP-7","description":"\u003cp\u003eThe product contains the polyhedrin protein co-crystalized with Human BMP-7. BMP-7, also known as Bone Morphogenetic Protein 7, osteogenic protein-1 or OP-1, is a member of the TGF superfamily of proteins. Akin to the other functionally and structurally related bone morphogenic proteins (BMPs), BMP-7 is involved in cartilage and bone formation and signals through serine\/threonine kinase receptors. Additionally, BMP-7 plays a role in a variety of other organs and organ systems such as during development of the kidney and prostate. Furthermore, BMP-7 has been identified as an anti-fibrotic molecule, antagonizing TGF-?1 and the emergence of fibroblasts derived from endothelial cells in fibrosis of kidney, lung, liver, heart and peritoneum. BMP-7 was also implicated in the promotion of neuroregeneration following brain ischemia. The BMP-7 protein is usually a disulfide-linked homodimer and highly conserved across animal species; for example, the amino acid sequence of human, mouse and rat BMP-7 are 98% identical. However, mature BMP-7 can also form disulfide-linked heterodimers with either BMP-2 or BMP-4. These hetrodimeric complexes have shown increased effects and range of activity compared to BMP-7 homodimers.\u003c\/p\u003e","brand":"Cell Guidance Systems","offers":[{"title":"5 ug","offer_id":49302537044224,"sku":"CGS-PPH58-5","price":71.62,"currency_code":"NZD","in_stock":true},{"title":"25 ug","offer_id":49302537076992,"sku":"CGS-PPH58-25","price":278.51,"currency_code":"NZD","in_stock":true},{"title":"250 ug","offer_id":49302537109760,"sku":"CGS-PPH58-250","price":1352.78,"currency_code":"NZD","in_stock":true},{"title":"1 mg","offer_id":49302537142528,"sku":"CGS-PPH58-1000","price":4456.23,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0663\/6591\/5392\/files\/PODS_protein_crystals1_d556748e-af4a-46b5-9bdb-e989957258a4.jpg?v=1787289864","url":"https:\/\/shop.customscience.co.nz\/products\/pods-human-bmp-7","provider":"Custom Science Ltd","version":"1.0","type":"link"}