PODS Human CDNF
SKU CGS-PPH347-50
Original price
$357.89
-
Original price
$3,431.58
Original price
$357.89
$357.89
-
$3,431.58
Current price
$357.89
The product contains the polyhedrin protein co-crystalized with Human CDNF. Cerebral Dopamine Neurotrophic Factor (CDNF) and MANF (mesencephalic-astrocyte-derived neurotrophic factor) are structural homologues and share 62% amino acid (aa) identity. Furthermore, CDNF is highly conserved across species. It shares 80%, 84%, 90% and 92% aa identity with mouse, rat, equine and bovine CDNF, respectively. Like MANF and GDNF, CDNF is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine-specific neurons (DNs) in vitro. Additionally, in rat Parkinson's disease models that rely on 6-hydroxydopamine (6-OHDA)-induced degeneration of DNs, CDNF can also promote rescue and restoration of DNs in the substania nigra in vivo.
Delivery time
Overnight if in stock
Payment Methods
Purchase orders from approved customers and Credit Cards are accepted as forms of payment