The product contains the polyhedrin protein co-crystalized with Human IL-33. Also known as NF-HEV and DVS 27, IL-33 is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. It is a proinflammatory cytokine which binds and signals through the IL-1RL1/ST2 receptor to activate NF-?-B and MAPK signalling pathways. IL-33 functions to induce type 2-associated cytokine production in polarized Type 2 helper T (Th2) cells.