Recognizes endogenous levels of Aconitase 2 protein.
Aconitase 2 (ACO2) catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle. ACO2 is also an important regulator of iron homeostasis within cells. In addition, research studies have shown that this enzyme is deficient in the mitochondrial disease Friedreich's Ataxia.
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