Recognizes endogenous levels of Beta-catenin protein.
by Bioworld
SKU BW-MB66283-50ul
Original price
$354.14
-
Original price
$616.38
Original price
$354.14
$354.14
-
$616.38
Current price
$354.14
?-catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates ?-catenin at Ser45. This phosphorylation event primes ?-catenin for subsequent phosphorylation by GSK-3?. GSK-3? destabilizes ?-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of ?-catenin protein levels and have been found in many tumor cell lines.
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