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Recognizes endogenous levels of CD106 protein.

SKU BW-BS67731-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

VCAM-1 (vascular cell adhesion molecule-1) is a transmembrane glycoprotein containing multiple amino-terminal extracellular Ig-like domains, a transmembrane domain, and a short carboxy-terminal cytoplasmic domain. Alternative splicing generates two isoforms of VCAM-1. The role of VCAM-1 during infection and inflammatory diseases is well characterized. Expression of VCAM-1 is induced in endothelial cells by inflammatory cytokines including TNF-? and IL-1?. VCAM-1 on endothelial cells interacts with the integrin VLA-4 (?4?1) on leukocytes to mediate migration of circulating leukocytes from the blood across the endothelium and into tissues.

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