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Recognizes endogenous levels of CD8a protein.

SKU BW-BS67743-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated ? and ? subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8? interacts with the ?3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the ? chain recruits the tyrosine kinase Lck, which is essential for T cell activation.

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