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Recognizes endogenous levels of DLC1 protein.

SKU BW-BS67463-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Loss of expression of deleted in liver cancer 1 (DLC-1) protein correlates strongly with cancerous phenotype in a large number of human tissues, such as breast, liver, colon and prostate, and generally occurs due to genomic deletion or aberrant promotor methylation. The gene encoding DLC-1 maps to human chromasome 8p22, a region presumed to harbor tumor supressor genes based on its frequent mutation in a large number of cancers. DLC-1 localizes to the cytoplasm and restored expression leads to caspase-3 mediated apoptosis, and inhibition of cell growth and invasiveness.

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