ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence family of transcription factors that share a unique and highly conserved DNA binding domain . ETS-1 plays important roles in vascular development and angiogenesis, and vascular inflammation and remodeling . The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecules . In addition, ETS-1 is involved in regulation of energy metabolism in cancer cells . ETS-1 activity is regulated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity , phosphorylation at its Thr38 site by Ras activates ETS-1 .