Recognizes endogenous levels of GBA protein.
b-glucosidase is a predominantly liver enzyme which efficiently hydrolyzes b-D-glucoside and b-D-galactoside. Defects in b-glucosidase cause Gaucher disease, an inherited condition distinguished by the accumulation of glucosylceramide within the cells of the reticuloendothelial system. b-glucosidase is used in enzyme replacement treatment aimed at treating Gaucher disease. The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial b-glucosidases.
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