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Recognizes endogenous levels of GPx-4 protein.

SKU BW-BS67575-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

The selenoprotein glutathione peroxidase 4 (GPX4) is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation . GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis . Research studies show that selenium enhances GPX4 expression and inhibits ferroptotic death to protect neurons . In addition, some therapy-resistant cancer cells depend on GPX4 to survive. Loss of GPX4 leads to ferroptosis and thus prevents tumor relapse in mice . Furthermore, redox homeostasis mediated by GPX4 is essential for activation of the cytosolic DNA-sensing cGAS-STING pathway and initiation of the subsequent innate immune response .

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