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Recognizes endogenous levels of IL-1 beta protein.

SKU BW-BS67482-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Interleukin-1? (IL-1?), one of the major caspase-1 targets, is a multifunctional cytokine that is involved in a host of immune and proinflammatory responses . It is produced primarily by activated monocytes and macrophages. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets . Human IL-1? is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form . Detection of the 17 kDa mature form of IL-1? is a good indicator of caspase-1 activity.

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