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Recognizes endogenous levels of Paxillin protein.

SKU BW-BS67453-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix . Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization . Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 . Phospho-paxillin (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin.

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