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Recognizes endogenous levels of PERK protein.

SKU BW-MB66377-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Protein kinase-like endoplasmic reticulum kinase (PERK) is an eIF2? kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition . ER stress increases the activity of PERK, which then phosphorylates eIF2? to promote reduced translation. Research studies have demonstrated that PERK-deficient mice have defects in pancreatic ? cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress . PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain . Phosphorylation of PERK at Thr980 serves as a marker for its activation status.

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