Recognizes endogenous levels of PRMT6 protein.
Protein arginine N-methyltransferase 6 (PRMT6) is a member of the protein arginine N-methyltransferase (PRMT) family of proteins that catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a guanidine nitrogen of arginine . The three types of PRMTs share the ability to mono-methylate arginine residues, but vary in their ability to generate differential methylation states . Mono-methylated arginine residues are further methylated by type I PRMTs to generate an asymmetric di-methyl arginine or by type II PRMTs to form a symmetric-dimethyl arginine. Type III methyltransferases are only able to mono-methylate arginine residues . PRMT6 is a type I PRMT that acts as both a transcriptional coactivator and a corepressor and catalyzes the asymmetric di-methylation of histone H3 (Arg 2, Arg42), histone H4 (Arg3), and histone H2A at Arg29 . PRMT6 acts as a coactivator for transcription factors, including estrogen receptor and NF?B, while asymmetric di-methylation of histone H3 (Arg2) by PRMT6 prevents MLL methylation of histone H3 at Lys4 and inhibits transcription activation . In addition to its role in regulating transcription, PRMT6 methylates DNA polymerase ?, leading to enhanced DNA binding and processivity during base excision repair of damaged DNA .
Delivery time
Overnight if in stock
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