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Recognizes endogenous levels of R Cadherin protein.

SKU BW-BS67470-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development . The classic cadherin subfamily includes N-, P-, R-, B-, and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with ?-catenin, ?-catenin (also called plakoglobin), and p120 catenin. ?-catenin and ?-catenin associate with ?-catenin, which links the cadherin-catenin complex to the actin cytoskeleton . While ?- and ?-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking ). Investigators consider E-cadherin an active suppressor of invasion and growth of many epithelial cancers ). Research studies indicate that cancer cells have upregulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch." N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion . Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis . Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers.

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