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Recognizes endogenous levels of Survivin protein.

SKU BW-MB66388-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy . Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division . This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase . Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth .

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