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RXR alpha (Phospho-S260) polyclonal antibody detects endogenous levels of RXR alpha protein only when phosphorylated at Ser260.

SKU BW-BS64567-50ul
Original price $466.21 - Original price $802.41
Original price
$466.21
$466.21 - $802.41
Current price $466.21

The human retinoid X receptors (RXRs) are encoded by three distinct genes (RXR?, RXR?, and RXR?) and bind selectively and with high affinity to the vitamin A derivative, 9-cis-retinoic acid. RXRs are type-II nuclear hormone receptors that are largely localized to the nuclear compartment independent of ligand binding. Nuclear RXRs form heterodimers with nuclear hormone receptor subfamily 1 proteins, including thyroid hormone receptor, retinoic acid receptors, vitamin D receptor, peroxisome proliferator-activated receptors, liver X receptors, and farnesoid X receptor. Since RXRs heterodimerize with multiple nuclear hormone receptors, they play a central role in transcriptional control of numerous hormonal signaling pathways by binding to cis-acting response elements in the promoter/enhancer region of target genes. Retinoid X receptor ? (RXR?) is the founding RXR family member and is predominantly expressed in liver, kidney, epidermis, intestine and a variety of tissues. Knockout of the murine rxr? gene results in embryonic lethality tentatively due to myocardial hypoplasia, which demonstrates the importance of RXR? to retinoid signaling in vivo. Biochemical evidence suggests that RXR? transcriptional activity is post-translationally regulated through the Ras-Raf-MAPK signaling cascade. MAPK-dependent phosphorylation of RXR? directly abrogates the ability of RXR? to associate with nuclear receptor coactivators.

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