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TBK1 polyclonal antibody detects endogenous levels of TBK1 protein.

SKU BW-BS62250-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14
$354.14 - $616.38
Current price $354.14

The transcription factor NF?B is retained in the cytoplasm in an inactive form by the inhibitory protein I?B. Activation of NF?B requires that I?B be phosphorylated on specific serine residues, which results in targeted degradation of I?B. I?B kinase ? (IKK?), previously designated CHUK, interacts with IkB-a and specifically phosphorylates I?B-? on the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKK?, IKK? and IKK? (also designated NEMO), and each appear to make essential contributions to I?B phosphorylation. TANK binding kinase (TBK1), also designated T2K, is a novel IKK-related kinase that has been identified in murine and human tissues. TBK1 was shown to complex with TRAF2 and TANK in the NF?B activation pathway. TBK1 shares homology with IKK? and IKK? in the amino-terminal half, which includes the kinase domain.

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