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TCF-1 (F26) polyclonal antibody detects endogenous levels of TCF-1 protein.

SKU BW-BS1987-50ul
Original price $354.14 - Original price $616.38
Original price
$354.14 - $616.38
Current price $354.14

T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic ?-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The ?-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates ?-catenin and, in turn, increases the degradation of cytosolic ?-catenin and inhibits the transcriptional activity of the TCF proteins.

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