Vascular endothelial cell growth inhibitor (VEGI also known as TNFRSF15 or TL1), a member of the TNF superfamily, has a signaling pathway similar to TNF and is most likely a multifunctional cytokine. VEGI is found in brain, reproductive, and late developmental stage embryonic tissues and expressed predominantly in endothelial cells. VEGI is an angiogenesis inhibitor of the TNF family and functions in part by directly inhibiting endothelial cell proliferation.VEGI may act as an autocrine factor to induce apoptosis in endothelial cells via activation of multiple signaling pathways, including stress protein kinases as well as certain caspases