Small Molecules

Rosiglitazone is a potent and selective agonist for PPAR gamma (Peroxisome proliferator-activated receptor). PPAR gamma plays a functional role in ...

RG108 is a non-nucleoside DNA methyltransferase (DMNT) inhibitor. RG108 effectively blocked DNA methyltransferases in-vitro and does not cause cova...

Reversine is a novel class of ATP-competitive Aurora kinase inhibitors. Reversine inhibits the phosphorylation of histone H3, a direct downstream t...

Reboxetine is a potent and selective norepinephrine reuptake inhibitor. It displays more than 1000-fold selectivity over alpha-adrenoceptors, 5-HT,...

Rapamycin is a specific inhibitor of mTOR (mammalian target of Rapamycin). It forms a complex with FKBP12 that binds to and inhibits mTOR. It also ...

Purmorphamine is an agonist of the protein Smoothened (Hh), a key part of the hedgehog signaling pathway, which is involved in bone growth and brai...

PTK787 is an inhibitor of VEGFR2/KDR, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. PTK787 also inhibits Flk, c-Kit and PDGFR-β.

PP1 is a selective and potent Src-family tyrosine kinase inhibitor. PP1 studies have proved its ability to potently inhibit Lck and Fyn (FynT), IL-...

Plerixafor is a bicyclam molecule that antagonizes the binding of the chemokine stromal cell-derived factor-1 (SDF-1) to its cognate receptor CXCR4...

PIK-75 is a cell-permeable selective inhibitor of PI 3-kinase p110alpha.

Pifithrin μ selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and it is...

PD98059 is a potent and selective cell permeable inhibitor of MAP kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the...

PD184352 is a highly selective non-competitive inhibitor of MEK, a kinase upstream in the mitogen-activated protein kinase pathway (MAPK).

The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor ...

PD0325901, a MEK inhibitor, is a synthetic organic molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK).

NVP-BEZ235 is a PI 3-kinase (PI3K) tyrosine kinase inhibitor and shows dual PI3K/mTOR inhibition. NVP-BEZ235 also inhibits ATR. However, NVP-BEZ235...

LY411575 is a potent gamma secretase inhibitor. It is able to block Notch activation and reduces A beta/42 post treatment (acute or chronic).

LY294002 shows a highly selective inhibitor of PI3K in-vivo. LY294002 can transfer cells to specific inhibition of PI3K, inhibition of PI3K/Akt sig...

LDN193189 is a highly potent small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3. BMPs induce Smad1/5/8 plu...

KY02111 is a Wnt signaling pathway inhibitor.

JNJ-10198409 is a potent ATP-competitive inhibitor of Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK).

IWP-2 is an inhibitor of Wnt processing and secretion. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn activ...

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3 beta (GSK-3 beta) inhibitor, activating downstream components ...

Irinotecan hydrochloride trihydrate (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in ce...