Small Molecules

ID-8 is a DYRK inhibitor.

GX15-070 is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl...

GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor, active for ROCK1 and ROCK2. GSK429286A is a more selective ROCK2 ...

Go 6983 is a protein kinase C (PKC) inhibitor.

Geldanamycin is a natural existing HSP90 (Heat Schock Protein 90) inhibitor, specifically disrupts glucocorticoid receptor (GR)/HSP association. Th...

GDC-0941 is a cell-permeable, selective small molecule that inhibits Class I phosphatidylinositide 3-kinase (PI3K).

GDC-0449 is a potent and specific Hedgehog signaling pathway inhibitor.

Garcinol is a polyisoprenylated benzophenone derivative from the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransfera...

Forskolin is a cAMP pathway activator, by activating adenylyl cyclase.

Fasudil hydrochloride is a cyclic nucleotide-dependent Rho-associated kinase inhibitor. The Rho-kinase (ROCK) mediates vasoconstriction and vascula...

Dorsomorphin is a BMP pathway inhibitor, which inhibits bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK...

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties...

Decitabine is a potent inhibitor of DNA methylation in different kinds of cells. Decitabine has been reported to cause phosphorylation inhibition o...

Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit.

DAPT is a potent and specific inhibitor of gamma-secretase. This reduces antibody levels in-vivo in plasma and cerebrospinal fluid. It blocks the p...

CYT387 is an ATP competitive inhibitor of JAK1 and JAK2 (Janus kinases).

Cyclosporin A is a non-polar cyclic oligopeptide metabolite. It possesses potent immunosuppressive properties, affecting primarly T-lymphocytes. Cy...

CHIR99021 is an aminopyrimidine derivative. CHIR99021 inhibits GSK3 beta (IC50 = 6.7 nM) and GSK3 alpha (IC50 = 10 nM) and functions as a WNT pathw...

BIX01294 is a G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM, respectively) that displays no a...

BIRB796 is a protein kinase inhibitor of p38 MAPK. BIRB796 has high picomolar affinity for p38 MAP kinase and low nanomolar inhibitory activity aga...

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms, which inhibits RSK1, RSK2, RSK3 and RSK4 in-vitro. BI-D1870 does no...

ALK5 Inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50 = 23 nM, 4 nM and 18 nM for binding...

A769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). It activates beta1-containing AMPK complexes, but induces glucose...

5-Azacytidine is an epigenetic modifier, a potent growth inhibitor and a cytotoxic agent.