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14-3-3 zeta (Phospho-T232) polyclonal antibody detects endogenous levels of 14-3-3 zeta protein only when phosphorylated at Thr232.

SKU BW-BS64514-50ul
Original price $466.21 - Original price $802.41
Original price
$466.21
$466.21 - $802.41
Current price $466.21

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 ?, ?, ?, ?, ?, ? and ?. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

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