Cell Guidance Systems

Rosiglitazone is a potent and selective agonist for PPAR gamma (Peroxisome proliferator-activated receptor). PPAR gamma plays a functional role in ...

Ruxolitinib is a JAK inhibitor of JAK1, JAK2, and JAK3. JAKs, or Janus-associated kinases, are tyrosine kinases found in the cytoplasm that are kno...

SAHA (suberoylanilide hydroxamic acid) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs.

SB203580 is a specific inhibitor of p38-MAPK pathway. SB203580 also inhibits protein kinase B (PKB, also known as Akt) and TLR signaling pathway.

SB216763 is a potent, selective, and cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor. It competes with ATP and potently inhibits the ac...

SB431542 is a potent and selective inhibitor of the TGF-β superfamily type 1 (TGF-β 1) activin receptor-like kinase (ALK5) receptors, and its relat...

SB590885 is another selective small-molecule inhibitor of the B-Raf kinase. It has been used to overcome the dependence of MAPK signaling and tumor...

Stem Cell Factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in ...

Stem Cell Factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in ...

Stromal cell-derived factor-1 α (SDF-1 α), also known as CXCL12a, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulat...

Stromal cell-derived factor-1 β (SDF-1 β), also known as CXCL12b, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulat...

Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and inverteb...

Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and inverteb...

Sorafenib is a multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth ...

SP600125 is a potent, selective and reversible inhibitor of the three JNK enzymes (c-Jun N-terminal kinases). Inhibition is competitive with respec...

Stauprimide is an indolocarbazole semi-synthetic small molecule. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating...

Staurosporine is a potent inhibitor of phospholipid/calcium-dependent protein kinase. It also inhibits the upregulation of VEGF expression in tumor...

StemRegenin 1 is an AhR inhibitor. StemRegenin 1 induces CD34+ cell expansion by binding and antagonizing AhR.

SU5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor. Multip...

SU6668 is an ATP-competitive PDGFR, Flk-1/KDR and FGFR inhibitor. It presents little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2. I...

Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFR beta. It also inhibits c-Kit. Sunitinib inhibits cellular receptor p...

Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor. Tandutinib inhibits the autophosphorylation of Flt-3/Flk-2 (FMS-Like Ty...

Thymus and Activation Regulated Chemokine (TARC), also known as CCL17, is a chemokine that is constitutively produced by thymus tissue and activate...

TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor.TG101348 also inhibits FLT3 and RET.