ATF6B (S425) polyclonal antibody detects endogenous levels of ATF6B protein.
ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6? homodimer or an ATF-6?/? heterodimer. Binding of the ATF-6? homodimer or ATF-6?/? heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription.
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