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IL-21

SKU CGS-GFH90-10
Original price $442.11 - Original price $14,051.58
Original price
$442.11
$442.11 - $14,051.58
Current price $442.11
Interleukin-21 (IL-21) is a member of the common-γ chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and Natural Killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.

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Overnight if in stock

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