La-related protein 1 (LARP1), also known as KIAA0731, is a 1,096 amino acid protein belonging to the LARP family. LARP1 contains two conserved regions, one that shares homology with La/SSB proteins and one that is conserved only across LARP family proteins. Within the La/SSB conserved region, LARP1 contains a HTH La-type RNA-binding domain, which may indicate a role in RNA stabalization and folding. Upon DNA damage, LARP1 is phosphorylated by ATR or ATM. LARP1 interacts with many signaling intermediate proteins, including 14-3-3 ?, 14-3-3 ?, 14-3-3 ? and 14-3-3 . Widely expressed, LARP1 levels are highest in heart. LARP1 exists as three isoforms produced by alternative splicing.